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Uninstalled and reinstalled Pixillion several times. Rebooted computer in between, etc. However the problem persists: most TIFF-files cannot be loaded in Pixillion. The files must be okay since the NCH Helpdesk can read them. Also other NCH software that I have can read them, the files have been read in the past by Pixillion, they load properly in various other apps, etc. So I am sure that the files are not the problem, but Pixillion on my computer is. 

The NCH support has gone quiet (because of the weekend maybe) so any suggestion is welcomed. 

Thanks Elk. I had a paid version of Pixillion which I bought through the Microsoft store. After removing Pixillion from my computer I cannot find it anymore in my store library. I am trying to contact NCH for a link to the paid app.

Suddenly Pixxilion refuses to convert almost all TIFF files. When adding TIFF-files an error message appears: çorrupted or invalid file, load failed'. This happens also with files that were previously loaded in Pixillion with no problem (and converted)! I rebooted the computer, tried different disks, settings, ran the repair function, etc. When I convert a "corrupted" TIFF-file to JPG through another program, Pixillion reads the JPG-file with no problem. . . .