I didn't have this problem when I first installed Uplink and Axon a while ago. There was just the freezing problem.
I tried to give it another chance with the latest version.
I configured Axon and Skype according to the NCH suggestions http://www.nch.com.au/kb/10034.html
There is a usual phone connected to a Fritz!Box SIP adapter, that registers to Axon at extension 101.
If I call Skype test service, I can't hear anything. However, the phone's microphone seems to work. Because if I change the audio out device to standard in Skype, I can hear through my computer's speakers and I can reco