It's all about trial and error with these settings. Also, some of the settings like mp4, avi, etc may mean you will need a different media player outside of Debut. I'm not the most experienced by any means, but noticed that no one was answering so thought I would try to help. My settings...I have a really nice video card so the quality is easier to come by. The basic principal is, the better performance you want on the video and audio is going to be a larger file saved....but if it doesn't matter the size then max it out. If you are limited then find the happy medium.